Pet Recall Facts

Ingredients / Afoxolaner

Afoxolaner: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

70,982Total reports
65,807Dog reports
84Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

201323
20143,059
20155,900
20167,742
20177,812
20185,215
20195,554
20205,214
20214,447
20223,859
20234,415
20247,182
20257,279
20263,281

Species named in reports

Dog65,807
Not given4,988
Human92
Cat84
Other3
Other Canids3
Horse1
Fox1

Signs reported after Afoxolaner

Vomiting16,237
Lethargy (see also Central nervous system depression in Neurological)7,337
Diarrhoea6,244
Lack of efficacy (ectoparasite) - tick NOS5,199
Lack of efficacy (ectoparasite) - flea4,631
Seizure NOS4,512
Lack of efficacy (bacteria) - Borrelia3,841
Lack of efficacy (tick)3,389
Skin disorders NOS2,625
Lack of efficacy (bacteria) - NOS2,607
Pruritus2,455
Tablets, Abnormal2,434
Itching2,189
Lack of efficacy (endoparasite) - heartworm1,878
Not eating1,848
Anorexia1,836
Lack of efficacy (flea)1,632
Panting1,557
Behavioural disorder NOS1,470
Lack of efficacy (endoparasite) - hookworm1,411
Shaking1,322
Lack of efficacy (bacteria) - Anaplasma1,311
Scratching1,258
Other abnormal test result NOS1,209
Ataxia1,204

Breeds named in reports

Retriever - Labrador7,529
Dog (unknown)6,773
Retriever - Golden4,583
Crossbred Canine/dog3,964
Shepherd Dog - German2,855
Poodle - Standard2,532
Shih Tzu2,493
Chihuahua2,420
Terrier - Yorkshire2,282
Pit Bull1,868
Shepherd Dog - Australian1,829
Poodle - Miniature1,735
Beagle1,534
Maltese1,341
Boxer (German Boxer)1,199

Reported outcomes

Outcome Unknown37,562
Recovered/Normal19,928
Ongoing6,292
Died1,220
Euthanized810
Recovered with Sequela144

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