Pet Recall Facts

Ingredients / Estriol

Estriol: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

2,049Total reports
2,019Dog reports
2Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

20117
201240
2013249
2014226
2015155
2016136
2017132
2018131
2019141
2020141
2021107
202295
2023106
2024140
2025164
202679

Species named in reports

Dog2,019
Not given21
Human6
Cat2
Rat1

Signs reported after Estriol

Lack of efficacy - NOS674
Swollen vulva342
Lethargy (see also Central nervous system depression in Neurological)137
Death by euthanasia117
Vomiting114
Anorexia100
Urinary incontinence90
Vaginal swelling90
Diarrhoea85
Decreased appetite81
Urinary tract infection80
Vaginal discharge80
Weight loss77
Polydipsia74
Genital tract licking68
Vaginal haemorrhage67
Emesis (multiple)66
Thrombocytopenia62
Elevated alanine aminotransferase (ALT)60
Seizure NOS58
Polyuria53
Other abnormal test result NOS53
Elevated blood urea nitrogen (BUN)50
Not eating49
Anaemia NOS46

Breeds named in reports

Crossbred Canine/dog404
Retriever - Labrador184
Dog (unknown)112
Shepherd Dog - German98
Doberman Pinscher97
Terrier - Yorkshire68
Boxer (German Boxer)54
Siberian Husky49
Collie - Border41
Poodle - Miniature41
Poodle (unspecified)40
Shepherd Dog - Australian40
Pit Bull40
Chihuahua37
Terrier (unspecified)35

Reported outcomes

Ongoing910
Recovered/Normal310
Outcome Unknown268
Euthanized95
Died42
Recovered with Sequela32

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