Pet Recall Facts

Ingredients / Milbemycin Oxime

Milbemycin Oxime: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

240,391Total reports
222,771Dog reports
755Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

199027
199168
199238
199329
199416
199527
199664
199758
1998202
1999766
2000738
2001561
2002389
2003550
20041,547
20052,038
20062,806
20073,712
20084,266
20094,645
20104,189
201111,665
201225,502
201326,828
201422,786
201519,937
201617,095
201716,234
201814,735
201913,604
202011,981
20218,684
20226,472
20235,625
20245,812
20254,843
20261,851

Species named in reports

Dog222,771
Not given16,278
Cat755
Human494
Other64
Other Canids11
Rabbit4
Wolf4

Signs reported after Milbemycin Oxime

Vomiting46,935
Emesis43,166
Lethargy (see also Central nervous system depression in Neurological)23,571
INEFFECTIVE, HEARTWORM LARVAE22,420
Lack of efficacy (endoparasite) - heartworm16,651
Diarrhoea14,405
UNPALATABLE14,007
Lack of efficacy - NOS13,207
Lack of efficacy (endoparasite) - hookworm11,949
Lack of efficacy (ectoparasite) - flea8,585
Seizure NOS6,082
INEFFECTIVE, ASCARIDS NOS5,511
Behavioural disorder NOS5,106
INEFFECTIVE, HOOKS5,058
Anorexia4,999
Other abnormal test result NOS4,742
Lack of efficacy (endoparasite) - whipworm4,467
Ataxia4,329
Depression4,081
Not eating3,722
Emesis (multiple)3,683
Shaking3,455
Death3,421
Weight gain3,314
Product problem3,262

Breeds named in reports

Retriever - Labrador29,518
Dog (unknown)22,471
Crossbred Canine/dog22,435
Retriever - Golden9,852
Shepherd Dog - German9,430
Poodle (unspecified)8,749
Chihuahua8,707
Terrier - Yorkshire7,771
Shih Tzu7,058
Boxer (German Boxer)6,933
Pit Bull6,717
Beagle5,731
Shepherd Dog - Australian5,045
Dachshund (unspecified)4,887
Maltese4,535

Reported outcomes

Recovered/Normal92,682
Outcome Unknown65,335
Ongoing21,058
Recovered with Sequela6,968
Died4,194
Euthanized1,913

Report a problem to FDA