Pet Recall Facts

Ingredients / Pyriproxyfen

Pyriproxyfen: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

2,174Total reports
1,645Dog reports
519Cat reports

FDA-approved products with this ingredient (Green Book)

No matching Green Book entry is supplied in this dataset. This alone does not establish regulatory status.

EPA-registered pesticide. Flea and tick products with this ingredient, such as many collars, spot-ons and shampoos, are registered by the U.S. Environmental Protection Agency (EPA), not approved by FDA, so they have no FDA Green Book record. Pet owners still send reports about them to FDA, and those reports are counted here. Questions about these products: National Pesticide Information Center.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

20116
201295
2013146
2014128
2015130
2016131
2017257
2018207
2019191
2020168
2021161
2022155
2023124
2024139
2025101
202635

Species named in reports

Dog1,645
Cat519
Human6
Not given3
Rabbit1

Signs reported after Pyriproxyfen

Lack of efficacy (ectoparasite) - flea399
Lethargy (see also Central nervous system depression in Neurological)314
Pruritus309
Vomiting303
Behavioural disorder NOS175
Diarrhoea156
Other abnormal test result NOS99
Anorexia97
Emesis96
Seizure NOS93
Weight loss72
Application site pruritus68
Lack of efficacy (endoparasite) - tapeworm64
Ataxia62
Not eating56
Lack of efficacy (endoparasite) - heartworm56
Decreased appetite54
Vocalisation51
Death50
Emesis (multiple)50
Death by euthanasia50
Application site alopecia49
Panting49
Hyperactivity47
Agitation47

Breeds named in reports

Domestic Shorthair276
Retriever - Labrador181
Dog (unknown)151
Crossbred Canine/dog106
Cat (unknown)88
Retriever - Golden85
Chihuahua78
Shepherd Dog - German72
Pit Bull70
Terrier - Yorkshire69
Shih Tzu67
Shepherd Dog - Australian54
Domestic Longhair53
Poodle (unspecified)50
Maltese44

Reported outcomes

Outcome Unknown1,088
Recovered/Normal647
Ongoing319
Died52
Euthanized51
Recovered with Sequela15

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